Human Papillomavirus‐type distribution in anogenital lesions of prepubertal children
نویسندگان
چکیده
Background In contrast to adults, only limited data are available on the human papillomavirus (HPV)-type spectrum in anogenital warts (AGW) of children. Objective This study aimed evaluate HPV-type AGW prepubertal Materials & methods a retrospective German multicentre study, HPV genotyping was performed biopsies 55 1- 12-year-old children using group-specific PCRs followed by hybridization with type-specific probes or sequence analysis. Results Human papillomavirus-DNA found 53 AGW. 58.5% (31/53) HPV-positive AGW, mucosal types were detected. HPV6 (27/53, 50.9%) predominant type. 43.4% (23/53) lesions induced cutaneous (HPV2, HPV27, HPV57). Mucosal significantly more common under 5 years age than and older (22/25, 88.0% [95% CI: 70.0–95.8] vs. 9/28, 32.1% 17.9–50.7], P < 0.001). contrast, prevalent 5- 12-year group (4/25, 16.0% CI 6.4–34.7] 19/28, 67.9% 49.3–82.1], Conclusion Anogenital frequently associated types, possibly due horizontal transmission. typing, addition comprehensive clinical psychosocial evaluation, can potentially help assessment these cases.
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Kaposi's sarcoma (KS) is a low-grade vascular neoplasm associated with human herpes virus-8 (HHV-8) infection, and, in the epidemic form, with the human immunodeficiency virus (HIV). Although HHV-8 is present in all body fluids and is sexually transmitted, there are surprisingly few reports of anogenital KS. Clinically, especially in HIV/KS endemic areas, dark stained skin patches or nodules ar...
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ژورنال
عنوان ژورنال: Journal of The European Academy of Dermatology and Venereology
سال: 2021
ISSN: ['1468-3083', '0926-9959']
DOI: https://doi.org/10.1111/jdv.17114